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KMID : 0931320210210020135
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대한상부위장관.헬리코박터학회지
2021 Volume.21 No. 2 p.135 ~ p.143
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Proton-pump Inhibitors and the Risk of Dementia: A Systematic Review and Meta-analysis
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Yoon Kyu-Tae
Bang Chang-Seok
Kim Joon-Sung
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Abstract
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Background/Aims: Proton pump inhibitors (PPIs) are widely used to treat several acid-related gastrointestinal disorders. This study aimed to investigate the risk of dementia in patients taking PPIs.
Materials and Methods: A systematic review was conducted to evaluate the correlation between PPIs and dementia. The methodological quality of the included studies was evaluated using the Risk of Bias Assessment tool for non-randomized studies. Publication bias was assessed.
Results: A total of 12 nested, case-control, and cohort studies were identified and analyzed. We obtained hazard ratios (HRs) from five studies and performed a meta-analysis. The meta-analysis of four cohort studies and one nested case-control study showed no association between PPIs and dementia (HR, 1.165; 95% CI, 0.912~1.488; P=0.222). Sensitivity analysis revealed consistent results. No publication bias was detected.
Conclusions: This systematic review and meta-analysis revealed no statistically significant association between the use of PPIs and dementia.
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KEYWORD
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Alzheimer disease, Dementia, Proton pump inhibitors
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